Fulminant Infectious Mononucleosis and Recurrent Epstein‐Barr Virus Reactivation in an Adolescent | Zendy

Jamie P. Nourse | Zendy; Kimberley Jones | Zendy; Ujjwal Dua | Zendy; Naomi Runnegar | Zendy; David Looke | Zendy; Christopher Schmidt | Zendy; SiokKeen Tey | Zendy; Glen Kennedy | Zendy; Maher K. Gandhi | Zendy

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Fulminant Infectious Mononucleosis and Recurrent Epstein‐Barr Virus Reactivation in an Adolescent

Author(s) -

Jamie P. Nourse,

Kimberley Jones,

Ujjwal Dua,

Naomi Runnegar,

David Looke,

Christopher Schmidt,

SiokKeen Tey,

Glen Kennedy,

Maher K. Gandhi

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/650007

Subject(s) - mononucleosis , fulminant , medicine , epstein–barr virus infection , epstein–barr virus , virus , immunology , virology , immunity , transplantation , immune system

We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.

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