Transmission of HIV‐1 Drug‐Resistant Variants: Prevalence and Effect on Treatment Outcome | Zendy

Martin R. Jakobsen | Zendy; Martin Tolstrup | Zendy; Ole S. Søgaard | Zendy; Louise B. Jørgensen | Zendy; Paul R. Gorry | Zendy; Alex Lund Laursen | Zendy; Lars Østergaard | Zendy

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Transmission of HIV‐1 Drug‐Resistant Variants: Prevalence and Effect on Treatment Outcome

Author(s) -

Martin R. Jakobsen,

Martin Tolstrup,

Ole S. Søgaard,

Louise B. Jørgensen,

Paul R. Gorry,

Alex Lund Laursen,

Lars Østergaard

Publication year - 2010

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/650001

Subject(s) - medicine , reverse transcriptase , drug resistance , genotyping , virology , peripheral blood mononuclear cell , viral load , genotype , reverse transcriptase inhibitor , hiv drug resistance , multiplex , zidovudine , prospective cohort study , didanosine , antiretroviral therapy , human immunodeficiency virus (hiv) , viral disease , polymerase chain reaction , biology , bioinformatics , genetics , gene , in vitro

Human immunodeficiency virus type 1 (HIV-1) drug resistance is an important threat to the overall success of antiretroviral therapy (ART). Because of the limited sensitivity of commercial assays, transmitted drug resistance (TDR) may be underestimated; thus, the effect that TDR has on treatment outcome needs to be investigated. The objective of this study was to investigate the prevalence of TDR in HIV-infected patients and to evaluate the significance of TDR with respect to treatment outcome by analyzing plasma viral RNA and peripheral blood mononuclear cell proviral DNA for the presence of drug resistance mutations.

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