Open AccessHIV Infection and Aging Independently Affect Brain Function as Measured by Functional Magnetic Resonance Imaging
Author(s) -
Beau M. Ances,
Florin Vaida,
Melinda J. Yeh,
Christine Liang,
Richard B. Buxton,
Scott Letendre,
J. Allen McCutchan,
Ronald J. Ellis
Publication year - 2010
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/649899
Subject(s) - serostatus , functional magnetic resonance imaging , brain structure and function , magnetic resonance imaging , affect (linguistics) , medicine , human immunodeficiency virus (hiv) , biomarker , neuroimaging , psychology , neuroscience , immunology , biology , viral load , psychiatry , biochemistry , communication , radiology
We investigated the interactions between human immunodeficiency virus (HIV) infection and aging and their effects on brain function demands by means of functional magnetic resonance imaging (fMRI). A multiple-regression model was used to study the association and interaction between fMRI measures, HIV serostatus, and age for 26 HIV-infected subjects and 25 seronegative subjects. Although HIV serostatus and age independently affected fMRI measures, no interaction occurred. Functional brain demands in HIV-positive subjects were equivalent to those of HIV-negative subjects who were 15-20 years older. Frailty parallels between HIV infection and aging could result from continued immunological challenges depleting resources and triggering increased metabolic demands. In the future, fMRI could be a noninvasive biomarker to assess HIV infection in the brain.
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