Combination Flucytosine and High‐Dose Fluconazole Compared with Fluconazole Monotherapy for the Treatment of Cryptococcal Meningitis: A Randomized Trial in Malawi | Zendy

Jesse C. Nussbaum | Zendy; Arthur Jackson | Zendy; Dan Namarika | Zendy; Jacob Phulusa | Zendy; Jullita Kenala | Zendy; Creto Kanyemba | Zendy; Joseph N Jarvis | Zendy; Shabbar Jaffar | Zendy; Mina C. Hosseinipour | Zendy; Deborah Kamwendo | Zendy; Charles M. van der Horst | Zendy; Thomas S. Harrison | Zendy

Open Access

Combination Flucytosine and High‐Dose Fluconazole Compared with Fluconazole Monotherapy for the Treatment of Cryptococcal Meningitis: A Randomized Trial in Malawi

Author(s) -

Jesse C. Nussbaum,

Arthur Jackson,

Dan Namarika,

Jacob Phulusa,

Jullita Kenala,

Creto Kanyemba,

Joseph N Jarvis,

Shabbar Jaffar,

Mina C. Hosseinipour,

Deborah Kamwendo,

Charles M. van der Horst,

Thomas S. Harrison

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/649861

Subject(s) - fluconazole , flucytosine , medicine , amphotericin b , meningitis , cryptococcosis , neutropenia , mycosis , gastroenterology , surgery , chemotherapy , immunology , antifungal , dermatology

Cryptococcal meningitis is a major cause of human immunodeficiency virus (HIV)-associated morbidity and mortality in Africa. Improved oral treatment regimens are needed because amphotericin B is neither available nor feasible in many centers. Fluconazole at a dosage of 1200 mg per day is more fungicidal than at a dosage of 800 mg per day, but mortality rates remain unacceptably high. Therefore, we examined the effect of adding oral flucytosine to fluconazole.

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