Protein E ofHaemophilus influenzaeIs a Ubiquitous Highly Conserved Adhesin | Zendy

Birendra Singh | Zendy; Marta Brant | Zendy; Mogens Kilian | Zendy; Björn M. Hallström | Zendy; Kristian Riesbeck | Zendy

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Protein E ofHaemophilus influenzaeIs a Ubiquitous Highly Conserved Adhesin

Author(s) -

Birendra Singh,

Marta Brant,

Mogens Kilian,

Björn M. Hallström,

Kristian Riesbeck

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/649782

Subject(s) - bacterial adhesin , haemophilus influenzae , microbiology and biotechnology , haemophilus , pasteurellaceae , bacterial protein , biology , virology , escherichia coli , bacteria , genetics , gene , antibiotics

Protein E (PE) of nontypeable Haemophilus influenzae (NTHi) is involved in adhesion and activation of epithelial cells. A total of 186 clinical NTHi isolates, encapsulated H. influenzae, and culture collection strains were analyzed. PE was highly conserved in both NTHi and encapsulated H. influenzae (96.9%-100% identity without the signal peptide). PE also existed in other members of the genus Pasteurellaceae. The epithelial cell binding region (amino acids 84-108) was completely conserved. Phylogenetic analysis of the pe sequence separated Haemophilus species into 2 separate clusters. Importantly, PE was expressed in 98.4% of all NTHi (126 isolates) independently of the growth phase.

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