The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness | Zendy

William J. Doyle | Zendy; Margaretha L. Casselbrant | Zendy; HaSheng LiKorotky | Zendy; Allison P. Cullen Doyle | Zendy; ChiaYee Lo | Zendy; Ronald B. Turner | Zendy; Sheldon Cohen | Zendy

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The Interleukin 6 −174 C/C Genotype Predicts Greater Rhinovirus Illness

Author(s) -

William J. Doyle,

Margaretha L. Casselbrant,

HaSheng LiKorotky,

Allison P. Cullen Doyle,

ChiaYee Lo,

Ronald B. Turner,

Sheldon Cohen

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/649559

Subject(s) - seroconversion , immunology , rhinovirus , genotype , interleukin , medicine , immune system , biology , virus , cytokine , gene , genetics

In adults and children with respiratory syncytial virus (RSV) infection, a polymorphism in the interleukin 6 (IL-6) promoter at position -174 predicts illness magnitude. In addition, polymorphisms in the interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) genes are associated with immune responsiveness and the frequency of complications. Here, the effect of these polymorphisms on illness and seroconversion during infection with rhinovirus type 39 (RV39) was evaluated.

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