Factors Influencing Time to Vancomycin‐Induced Clearance of Nonendocarditis Methicillin‐ResistantStaphylococcus aureusBacteremia: Role of Platelet Microbicidal Protein Killing andagrGenotypes | Zendy

Pamela Moise | Zendy; Alan Forrest | Zendy; Arnold S. Bayer | Zendy; Yan Q. Xiong | Zendy; Michael R. Yeaman | Zendy; George Sakoulas | Zendy

Open Access

Factors Influencing Time to Vancomycin‐Induced Clearance of Nonendocarditis Methicillin‐ResistantStaphylococcus aureusBacteremia: Role of Platelet Microbicidal Protein Killing andagrGenotypes

Author(s) -

Pamela Moise,

Alan Forrest,

Arnold S. Bayer,

Yan Q. Xiong,

Michael R. Yeaman,

George Sakoulas

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/649429

Subject(s) - bacteremia , vancomycin , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , staphylococcal infections , endocarditis , medicine , meticillin , micrococcaceae , biology , minimum inhibitory concentration , immunology , antibacterial agent , antibiotics , bacteria , genetics

Vancomycin susceptibility, the accessory gene global regulator (agr) genotype and function, staphylococcal cassette chromosome (SCC) mec type, and susceptibility to cationic thrombin-induced platelet microbicidal protein 1 (tPMP-1) have been individually predictive of duration of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. This investigation evaluated the interrelationship of these factors with time to clearance of MRSA bacteremia during vancomycin therapy in patients without endocarditis.

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