CCR5 Deficiency Is a Risk Factor for Early Clinical Manifestations of West Nile Virus Infection but not for Viral Transmission | Zendy

Jean K. Lim | Zendy; David H. McDermott | Zendy; Andrea Lisco | Zendy; Gregory A. Foster | Zendy; David E. Krysztof | Zendy; Dean Follmann | Zendy; Susan L. Stramer | Zendy; Philip M. Murphy | Zendy

Open Access

CCR5 Deficiency Is a Risk Factor for Early Clinical Manifestations of West Nile Virus Infection but not for Viral Transmission

Author(s) -

Jean K. Lim,

David H. McDermott,

Andrea Lisco,

Gregory A. Foster,

David E. Krysztof,

Dean Follmann,

Susan L. Stramer,

Philip M. Murphy

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/649426

Subject(s) - flavivirus , risk factor , immunology , medicine , transmission (telecommunications) , disease , virology , chemokine receptor ccr5 , west nile virus , virus , biology , chemokine , chemokine receptor , immune system , electrical engineering , engineering

West Nile virus (WNV) is a neurotropic flavivirus transmitted to humans by mosquito vectors. Homozygosity for CCR5Delta32, a complete loss-of-function mutation in CC chemokine receptor 5 (CCR5), has been previously associated with severe symptomatic WNV infection in patients who present with clinical disease; however, whether it acts at the level of initial infection or in promoting clinical progression is unknown.

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