2‐Tiered Antibody Testing for Early and Late Lyme Disease Using Only an Immunoglobulin G Blot with the Addition of a VlsE Band as the Second‐Tier Test | Zendy

John A. Branda | Zendy; Maria E. AgueroRosenfeld | Zendy; Mary Jane Ferraro | Zendy; Barbara J. B. Johnson | Zendy; Gary P. Wormser | Zendy; Allen C. Steere | Zendy

Open Access

2‐Tiered Antibody Testing for Early and Late Lyme Disease Using Only an Immunoglobulin G Blot with the Addition of a VlsE Band as the Second‐Tier Test

Author(s) -

John A. Branda,

Maria E. AgueroRosenfeld,

Mary Jane Ferraro,

Barbara J. B. Johnson,

Gary P. Wormser,

Allen C. Steere

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/648674

Subject(s) - lyme disease , medicine , immunoglobulin m , immunology , antibody , immunoglobulin g , stage (stratigraphy) , erythema chronicum migrans , erythema migrans , carditis , neuroborreliosis , borrelia burgdorferi , arthritis , biology , paleontology , lyme borreliosis

Standard 2-tiered immunoglobulin G (IgG) testing has performed well in late Lyme disease (LD), but IgM testing early in the illness has been problematic. IgG VlsE antibody testing, by itself, improves early sensitivity, but may lower specificity. We studied whether elements of the 2 approaches could be combined to produce a second-tier IgG blot that performs well throughout the infection.

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