Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid | Zendy

MaryJo Lechowicz | Zendy; Dirk P. Dittmer | Zendy; Jeannette Lee | Zendy; Susan E. Krown | Zendy; William Wachsman | Zendy; David M. Aboulafia | Zendy; Bruce J. Dezube | Zendy; Lee Ratner | Zendy; Jonathan Said | Zendy; Richard F. Ambinder | Zendy

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Molecular and Clinical Assessment in the Treatment of AIDS Kaposi Sarcoma with Valproic Acid

Author(s) -

MaryJo Lechowicz,

Dirk P. Dittmer,

Jeannette Lee,

Susan E. Krown,

William Wachsman,

David M. Aboulafia,

Bruce J. Dezube,

Lee Ratner,

Jonathan Said,

Richard F. Ambinder

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/648447

Subject(s) - medicine , valproic acid , sarcoma , malignancy , clinical trial , toxicity , dermatology , sida , immunopathology , oncology , human immunodeficiency virus (hiv) , viral disease , virology , epilepsy , pathology , psychiatry

The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

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