Cytomegalovirus‐Specific T Cell Immunotherapy Promotes Restoration of Durable Functional Antiviral Immunity following Allogeneic Stem Cell Transplantation | Zendy

Karl S. Peggs | Zendy; Stephanie Verfuerth | Zendy; Arnold Pizzey | Zendy; ShoonLing C. Chow | Zendy; Kirsty Thomson | Zendy; Stephen Mackin | Zendy

Open Access

Cytomegalovirus‐Specific T Cell Immunotherapy Promotes Restoration of Durable Functional Antiviral Immunity following Allogeneic Stem Cell Transplantation

Author(s) -

Karl S. Peggs,

Stephanie Verfuerth,

Arnold Pizzey,

ShoonLing C. Chow,

Kirsty Thomson,

Stephen Mackin

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/648422

Subject(s) - immunology , medicine , stem cell , transplantation , immunotherapy , hematopoietic stem cell transplantation , cytomegalovirus , human cytomegalovirus , immune system , immunity , herpesviridae , t cell , virology , virus , viral disease , biology , genetics

The profound immunodeficiency associated with allogeneic hematopoietic stem cell transplantation is permissive to uncontrolled replication of latent human herpesviridae such as cytomegalovirus. Morbidity and mortality associated with viral dissemination or its treatment are significant. Although adoptive cellular therapy with virus-specific T cells offers the potential for accelerating pathogen-specific immune reconstitution, the risk of induction of graft-versus-host disease and the logistics of production of clonal T cell populations restrict application.

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