AListeria monocytogenesStrain Is Still Virulent despite Nonfunctional Major Virulence Genes | Zendy

Sylvie Roche | Zendy; Olivier Grépinet | Zendy; Y. Corde | Zendy; A.P. Teixeira | Zendy; Annaëlle Kérouanton | Zendy; Stéphanie Témoin | Zendy; Laurent Méreghetti | Zendy; Anne Brisabois | Zendy; Philippe Velge | Zendy

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AListeria monocytogenesStrain Is Still Virulent despite Nonfunctional Major Virulence Genes

Author(s) -

Sylvie Roche,

Olivier Grépinet,

Y. Corde,

A.P. Teixeira,

Annaëlle Kérouanton,

Stéphanie Témoin,

Laurent Méreghetti,

Anne Brisabois,

Philippe Velge

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/648402

Subject(s) - virulence , listeria monocytogenes , microbiology and biotechnology , biology , strain (injury) , gene , phospholipase , listeria , bacteria , genetics , enzyme , biochemistry , anatomy

The low-virulence Listeria monocytogenes strains have been previously assigned to 4 phenotypic groups. This study aimed to characterize the A23 strain, which exhibits a pulsed-field gel electrophoresis profile specific to low-virulence strains. This strain has the same causal mutations as the group III strains and a supplementary mutation in the mpl gene, leading to the absence of internalin A expression and the presence of inactive internalin B, phosphatidyl-inositol phospholipase C, and phosphatidylcholine phospholipase C. Despite these mutations in major virulence genes, the A23 strain formed plaques in cell monolayers and contaminated 100% of inoculated mice, suggesting that it evolved from group III strains by acquiring new virulence genes.

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