Conserved HIV‐1 Epitopes Continuously Elicit Subdominant Cytotoxic T‐Lymphocyte Responses | Zendy

Yi Liu | Zendy; John McNevin | Zendy; Morgane Rolland | Zendy; Hong Zhao | Zendy; Wenjie Deng | Zendy; Janine Maenza | Zendy; Claire E. Stevens | Zendy; Ann C. Collier | Zendy; M. Juliana McElrath | Zendy; James I. Mullins | Zendy

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Conserved HIV‐1 Epitopes Continuously Elicit Subdominant Cytotoxic T‐Lymphocyte Responses

Author(s) -

Yi Liu,

John McNevin,

Morgane Rolland,

Hong Zhao,

Wenjie Deng,

Janine Maenza,

Claire E. Stevens,

Ann C. Collier,

M. Juliana McElrath,

James I. Mullins

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/648401

Subject(s) - epitope , ctl* , subdominant , biology , virology , cytotoxic t cell , immunology , cd8 , conserved sequence , human leukocyte antigen , t cell , immune system , antibody , antigen , genetics , peptide sequence , gene , in vitro

The epitope specificities and antiviral activities of class I HLA-restricted CD8(+) T cells, especially those induced during human immunodeficiency virus type 1 (HIV-1) primary infection, are important considerations in designing HIV-1 vaccines. Conserved epitopes may be more commonly and persistently recognized than variable epitopes, as they may be more likely to be present in infecting viruses. However, some studies have shown preferential or similar targeting of variable versus conserved epitopes during primary infection.

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