Domain 3 of Hepatitis C Virus Core Protein Is Sufficient for Intracellular Lipid Accumulation | Zendy

Ravi Jhaveri | Zendy; Qiang Guan | Zendy; Anna Mae Diehl | Zendy

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Domain 3 of Hepatitis C Virus Core Protein Is Sufficient for Intracellular Lipid Accumulation

Author(s) -

Ravi Jhaveri,

Qiang Guan,

Anna Mae Diehl

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/648094

Subject(s) - steatosis , hepatitis c virus , genotype , virus , lipid droplet , fatty liver , intracellular , virology , lipid metabolism , biology , medicine , disease , gene , biochemistry , pathology , endocrinology

Hepatitis C virus (HCV) is a major cause of liver disease worldwide, with steatosis, or "fatty liver," being a frequent histologic finding. In previous work, we identified sequence polymorphisms within domain 3 (d3) of genotype 3 HCV core protein that correlated with steatosis and in vitro lipid accumulation. In this study, we investigated the sufficiency of d3 to promote lipid accumulation, the role of HCV genotype in d3 lipid accumulation, and the subcellular distribution of d3.

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