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One-third of the world's population is infected with tuberculosis, and 9 months of isoniazid monotherapy is the treatment of choice for latent tuberculosis infection. However, this approach has been associated with hepatotoxicity and poor compliance. A shorter (4-month) rifampin regimen has been evaluated in recent clinical trials.

clinical infectious diseases/clinical infectious diseases (online. university of chicago. press)

4 Months of Rifampin Compared with 9 Months of Isoniazid for the Management of Latent Tuberculosis Infection: A Meta‐analysis and Cost‐Effectiveness Study That Focuses on Compliance and Liver Toxicity