Peripheral CXCR3‐Associated Chemokines as Biomarkers of Fibrosis in Chronic Hepatitis C Virus Infection | Zendy

Marija Zeremski | Zendy; Rositsa B. Dimova | Zendy; Queenie B. Brown | Zendy; Ira M. Jacobson | Zendy; Marianthi Markatou | Zendy; Andrew H. Talal | Zendy

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Peripheral CXCR3‐Associated Chemokines as Biomarkers of Fibrosis in Chronic Hepatitis C Virus Infection

Author(s) -

Marija Zeremski,

Rositsa B. Dimova,

Queenie B. Brown,

Ira M. Jacobson,

Marianthi Markatou,

Andrew H. Talal

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/646614

Subject(s) - cxcl9 , hepatitis c virus , chemokine , cxcl11 , fibrosis , medicine , immunology , cxcr3 , inflammation , virus , hepatitis c , chronic hepatitis , chronic infection , virology , cxcl10 , pathology , chemokine receptor , immune system

CXCR3-associated chemokines CXCL9-CXCL11 promote histologic progression in chronic hepatitis C virus (HCV) infection, as indicated by elevated intrahepatic levels of messenger RNA in patients with advanced inflammation and fibrosis. We evaluated the potential of peripheral chemokine levels to discriminate among patients with chronic HCV infection who had different stages of fibrosis.

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