Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients | Zendy

Anne P.J. de Pagter | Zendy; Lianne Haveman | Zendy; Rob Schuurman | Zendy; Martin Schutten | Zendy; Marc Bierings | Zendy; Jaap Jan Boelens | Zendy

Open Access

Adenovirus DNA Positivity in Nasopharyngeal Aspirate Preceding Hematopoietic Stem Cell Transplantation: A Very Strong Risk Factor for Adenovirus DNAemia in Pediatric Patients

Author(s) -

Anne P.J. de Pagter,

Lianne Haveman,

Rob Schuurman,

Martin Schutten,

Marc Bierings,

Jaap Jan Boelens

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/644739

Subject(s) - hematopoietic stem cell transplantation , medicine , stem cell , transplantation , haematopoiesis , hazard ratio , immunology , virology , biology , confidence interval , genetics

Human adenovirus (HAdV)-positive nasopharyngeal aspirate preceding hematopoietic stem cell transplantation was prospectively analyzed in 62 patients. By multivariate Cox proportional hazard models, HAdV-positive nasopharyngeal aspirate was the only predictor for HAdV DNAemia after hematopoietic stem cell transplantation (P < .001). HAdV DNAemia was a predictor for alloreactive disease. Early detection and intervention might help to prevent HAdV disease after hematopoietic stem cell transplantation.

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