Comparison of Varicella‐Zoster Virus–Specific Immunity of Patients with Diabetes Mellitus and Healthy Individuals | Zendy

Shigefumi Okamoto | Zendy; Atsuko Hata | Zendy; Kay Sadaoka | Zendy; Koichi Yamanishi | Zendy; Yasuko Mori | Zendy

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Comparison of Varicella‐Zoster Virus–Specific Immunity of Patients with Diabetes Mellitus and Healthy Individuals

Author(s) -

Shigefumi Okamoto,

Atsuko Hata,

Kay Sadaoka,

Koichi Yamanishi,

Yasuko Mori

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/644646

Subject(s) - varicella zoster virus , medicine , diabetes mellitus , virus , immunity , immunology , population , immune system , endocrinology , environmental health

Cell-mediated immunity (CMI) has been shown to be critical for the prevention and control of varicella-zoster virus (VZV)-related diseases. Because a large population-based study has revealed that diabetes mellitus is a risk factor for herpes zoster, we studied VZV-specific immune responses of patients with diabetes mellitus and compared them with those of healthy individuals. In this study, we found that patients with diabetes mellitus had significantly lower CMI to VZV than did healthy individuals. These results suggest that the increased risk for herpes zoster among patients with diabetes mellitus may be related to decreased VZV-specific CMI.

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