Association of Mannose‐Binding Lectin Deficiency with Acute Invasive Aspergillosis in Immunocompromised Patients | Zendy

Jonathan Lambourne | Zendy; Dan Agranoff | Zendy; Raoul Herbrecht | Zendy; Peter F. Troke | Zendy; Aby Buchbinder | Zendy; Fenella Willis | Zendy; Valérie LetscherBru | Zendy; Samir Agrawal | Zendy; Sarah Doffman | Zendy; Elizabeth M. Johnson | Zendy; P. Lewis White | Zendy; Rosemary A. Barnes | Zendy; George E. Griffin | Zendy; Jodi A. Lindsay | Zendy; Thomas S. Harrison | Zendy

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Association of Mannose‐Binding Lectin Deficiency with Acute Invasive Aspergillosis in Immunocompromised Patients

Author(s) -

Jonathan Lambourne,

Dan Agranoff,

Raoul Herbrecht,

Peter F. Troke,

Aby Buchbinder,

Fenella Willis,

Valérie LetscherBru,

Samir Agrawal,

Sarah Doffman,

Elizabeth M. Johnson,

P. Lewis White,

Rosemary A. Barnes,

George E. Griffin,

Jodi A. Lindsay,

Thomas S. Harrison

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/644619

Subject(s) - mannan binding lectin , aspergillosis , immunology , medicine , lectin , aspergillus , biology , microbiology and biotechnology

Invasive aspergillosis is a devastating infection with attributable mortality of 40% despite antifungal therapy. In animal models of aspergillosis, deficiency of mannose-binding lectin (MBL), a pattern recognition receptor that activates complement, is a susceptibility factor. MBL deficiency occurs in 20%-30% of the population. We hypothesized that MBL deficiency may be a susceptibility factor for invasive aspergillosis in humans.

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