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Genetic Evidence for the Aggravation ofPlasmodium falciparumMalaria by Interleukin 4
Author(s) -
Sandrine Cabantous,
Belco Poudiougou,
Aboubacar Alassane Oumar,
Abdoualye Traore,
Abdoulaye Barry,
Joana Vitte,
Pierre Bongrand,
Sandrine Marquet,
Ogobara K. Doumbo,
Alain Dessein
Publication year - 2009
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/644600
Subject(s) - malaria , plasmodium falciparum , genotype , immunology , interleukin 4 , interleukin , variable number tandem repeat , medicine , biology , cytokine , genetics , gene
Severe malaria (SM) due to Plasmodium falciparum causes millions of child deaths in sub-Saharan Africa. It comprises a variety of clinical disorders, including cerebral malaria (CM) and severe anemia (SA). In previous work, we have shown that interferon gamma and interleukin 12 protect against CM. Here, we investigated whether interleukin 4 (IL-4) aggravates the risk of severe disease.

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