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Retention in Opioid Substitution Treatment: A Major Predictor of Long‐Term Virological Success for HIV‐Infected Injection Drug Users Receiving Antiretroviral Treatment
Author(s) -
Perrine Roux,
Patrizia Carrieri,
Julien Cohen,
Isabelle Ravaux,
Isabelle PoizotMartin,
P. Dellamonica,
Bruno Spire
Publication year - 2009
Publication title -
clinical infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.44
H-Index - 336
eISSN - 1537-6591
pISSN - 1058-4838
DOI - 10.1086/630209
Subject(s) - medicine , drug , human immunodeficiency virus (hiv) , opioid , antiretroviral therapy , opiate substitution treatment , term (time) , lentivirus , virology , viral load , drug holiday , sida , substitution (logic) , viral disease , oncology , pharmacology , buprenorphine , receptor , physics , quantum mechanics , computer science , programming language
The positive impact of opioid substitution treatment (OST) on opioid-dependent individuals with human immunodeficiency virus (HIV) infection is well documented, especially with regard to adherence to highly active antiretroviral therapy (HAART). We used the data from a 5-year longitudinal study of the MANIF 2000 cohort of individuals infected with HIV (as a result of injection drug use) and receiving HAART to investigate the predictors of long-term virological success. Design. Data were collected every 6 months from outpatient hospital services delivering HIV care in France. We selected all patients who were receiving HAART for at least 6 months (baseline visit) and who had indications for OST (ie, still dependent on opioids). We selected a total of 113 patients, accounting for a total of 562 visits for all the analyses.

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