Immunological and Biochemical Correlates of Adjunctive Dexamethasone in Vietnamese Adults with Bacterial Meningitis | Zendy

Nguyen Thi Hoang | Zendy; Trung Vu Tuan | Zendy; Marcel Wolbers | Zendy; Dang Minh Hoang | Zendy; Tran Vu Thieu Nga | Zendy; Tran Thi Hong Chau | Zendy; Ly Van Chuong | Zendy; Dinh Xuan Sinh | Zendy; Ho Dang Trung Nghia | Zendy; Nguyen Duy Phong | Zendy; Nguyen Hoan Phu | Zendy; To Song Diep | Zendy; Hoang Thi Thanh Hang | Zendy; Nguyễn Văn Vĩnh Châu | Zendy; Jeremy Farrar | Zendy; Constance Schultsz | Zendy; Tran Tinh Hien | Zendy; Cameron P. Simmons | Zendy

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Immunological and Biochemical Correlates of Adjunctive Dexamethasone in Vietnamese Adults with Bacterial Meningitis

Author(s) -

Nguyen Thi Hoang,

Trung Vu Tuan,

Marcel Wolbers,

Dang Minh Hoang,

Tran Vu Thieu Nga,

Tran Thi Hong Chau,

Ly Van Chuong,

Dinh Xuan Sinh,

Ho Dang Trung Nghia,

Nguyen Duy Phong,

Nguyen Hoan Phu,

To Song Diep,

Hoang Thi Thanh Hang,

Nguyễn Văn Vĩnh Châu,

Jeremy Farrar,

Constance Schultsz,

Tran Tinh Hien,

Cameron P. Simmons

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/630207

Subject(s) - medicine , dexamethasone , bacterial meningitis , meningitis , cerebrospinal fluid , placebo , vietnamese , randomized controlled trial , gastroenterology , immunology , surgery , pathology , linguistics , philosophy , alternative medicine

Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.

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