Very Late‐Onset Group BStreptococcusMeningitis, Sepsis, and Systemic Shigellosis due to Interleukin‐1 Receptor–Associated Kinase‐4 Deficiency | Zendy

Jens C. Krause | Zendy; Pegah Ghandil | Zendy; Maya Chrabieh | Zendy; JeanLaurent Casanova | Zendy; Capucine Pïcard | Zendy; Anne Puel | Zendy; C. Buddy Creech | Zendy

Open Access

Very Late‐Onset Group BStreptococcusMeningitis, Sepsis, and Systemic Shigellosis due to Interleukin‐1 Receptor–Associated Kinase‐4 Deficiency

Author(s) -

Jens C. Krause,

Pegah Ghandil,

Maya Chrabieh,

JeanLaurent Casanova,

Capucine Pïcard,

Anne Puel,

C. Buddy Creech

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/630206

Subject(s) - shigellosis , medicine , meningitis , group b , sepsis , streptococcus agalactiae , streptococcus , immunology , shigella , pediatrics , biology , genetics , bacteria , salmonella

We describe a child with very late-onset group B Streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. Peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. Sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations.

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