Multidrug‐Resistant Variants of HIV Type 1 (HIV‐1) Can Exist in Cells as Defective Quasispecies and Be Rescued by Superinfection with Other Defective HIV‐1 Variants | Zendy

Yudong Quan | Zendy; Chen Liang | Zendy; Bluma Brenner | Zendy; Mark A. Wainberg | Zendy

Open Access

Multidrug‐Resistant Variants of HIV Type 1 (HIV‐1) Can Exist in Cells as Defective Quasispecies and Be Rescued by Superinfection with Other Defective HIV‐1 Variants

Author(s) -

Yudong Quan,

Chen Liang,

Bluma Brenner,

Mark A. Wainberg

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/606117

Subject(s) - provirus , virology , viral quasispecies , superinfection , biology , reverse transcriptase , virus , samhd1 , mutation , multiple drug resistance , wild type , viral replication , reversion , drug resistance , genetics , mutant , rna , genome , gene , phenotype , hepatitis c virus

A tissue culture cell line infected with multidrug-resistant (MDR) human immunodeficiency virus type 1 (HIV-1) produced only noninfectious particles because of a lethal mutation in env. The defective MDR provirus was rescued by superinfection with either wild-type HIV-1 or a second replication-defective virus lethally mutated in capsid. Drug-resistance phenotyping revealed that the MDR viruses dominated if even single reverse-transcriptase inhibitors were present, reflecting linkage of the various drug resistance mutations on a single viral nucleic acid backbone. These results are most likely attributable to recombination during second rounds of infection and suggest that defective HIV-1 variants may nonetheless constitute part of the HIV-1 reservoir.

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