Resistance to Rotavirus Infection in Adult Volunteers Challenged with a Virulent G1P1A[8] Virus Correlated with Serum Immunoglobulin G Antibodies to Homotypic Viral Proteins 7 and 4 | Zendy

Lijuan Yuan | Zendy; Shinjiro Honma | Zendy; InYoung Kim | Zendy; Albert Z. Kapikian | Zendy; Yasutaka Hoshino | Zendy

Open Access

Resistance to Rotavirus Infection in Adult Volunteers Challenged with a Virulent G1P1A[8] Virus Correlated with Serum Immunoglobulin G Antibodies to Homotypic Viral Proteins 7 and 4

Author(s) -

Lijuan Yuan,

Shinjiro Honma,

InYoung Kim,

Albert Z. Kapikian,

Yasutaka Hoshino

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/606116

Subject(s) - antibody , rotavirus , virology , virus , virulence , immunoglobulin g , immunology , biology , medicine , gene , biochemistry

In a study performed in 1983, 18 adult volunteers received oral challenge with the virulent human rotavirus strain D (G1P1A[8],NSP4[B]). To identify correlates of resistance to rotavirus infection, we analyzed levels of serum immunoglobulin (Ig) A and IgG antibodies to various rotaviral antigens in 16 of the 18 volunteers.

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