Mannose‐Binding Lectin Is a Critical Factor in Systemic Complement Activation during Meningococcal Septic Shock | Zendy

Tom Sprong | Zendy; Tom Eirik Mollnes | Zendy; C. Neeleman | Zendy; Dorine W. Swinkels | Zendy; Mihai G. Netea | Zendy; J.W.M. van der Meer | Zendy; Marcel van Deuren | Zendy

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Mannose‐Binding Lectin Is a Critical Factor in Systemic Complement Activation during Meningococcal Septic Shock

Author(s) -

Tom Sprong,

Tom Eirik Mollnes,

C. Neeleman,

Dorine W. Swinkels,

Mihai G. Netea,

J.W.M. van der Meer,

Marcel van Deuren

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/606054

Subject(s) - mannan binding lectin , complement system , lectin pathway , septic shock , immunology , meningococcal disease , medicine , alternative complement pathway , atypical hemolytic uremic syndrome , sepsis , classical complement pathway , factor h , shock (circulatory) , neisseria meningitidis , lectin , biology , antibody , genetics , bacteria

Systemic activation of complement during meningococcal disease is associated with severe disease and poor outcome. The exact mechanism of activation of complement is unknown but is important for future therapies aimed at modulating the complement system in this disease.

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