Open AccessAntibody Responses in Oral Fluid after Administration of Prophylactic Human Papillomavirus Vaccines
Author(s) -
Ali RowhaniRahbar,
Joseph J. Carter,
Stephen E. Hawes,
James P. Hughes,
Noel S. Weiss,
Denise A. Galloway,
Laura A. Koutsky
Publication year - 2009
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/606026
Subject(s) - medicine , human papillomavirus , serology , confidence interval , antibody , hpv vaccines , prophylactic treatment , immunology , antibody response , hpv infection , cancer , cervical cancer
We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference standard, The sensitivity of oral fluid was 49.6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future.
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