Disparity in the In Vitro versus In Vivo Regulation of Fibronectin‐Binding Proteins by 2 Global Regulators,saeRSandsigB, inStaphylococcus aureus | Zendy

Ambrose L. Cheung | Zendy; SooJin Yang | Zendy; Arnold S. Bayer | Zendy; Yan Q. Xiong | Zendy

Open Access

Disparity in the In Vitro versus In Vivo Regulation of Fibronectin‐Binding Proteins by 2 Global Regulators,saeRSandsigB, inStaphylococcus aureus

Author(s) -

Ambrose L. Cheung,

SooJin Yang,

Arnold S. Bayer,

Yan Q. Xiong

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/606011

Subject(s) - fibronectin , staphylococcus aureus , in vitro , microbiology and biotechnology , in vivo , ex vivo , mutant , biology , chemistry , bacteria , biochemistry , gene , genetics , extracellular matrix

Fibronectin-binding protein A plays an important role in Staphylococcus aureus endovascular infections. We characterized the sigB-saeRS-fnbA expression network with fibronectin binding in vitro and in an experimental infective endocarditis (IE) model using parental strains RN6390 and SH1000 and their respective isogenic saeRS mutants. In contrast to the in vitro data, there was no influence of saeRS on fnbA expression in the IE model, yet ex vivo fibronectin binding was reduced in saeRS mutants. Moreover, as opposed to the in vitro findings, sigB appeared to have a positive rather than a negative effect on saeRS expression within cardiac vegetations.

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