Impaired Interferon‐γ Responses, Increased Interleukin‐17 Expression, and a Tumor Necrosis Factor–α Transcriptional Program in Invasive Aspergillosis | Zendy

Darius ArmstrongJames | Zendy; Suzy A. Turnbull | Zendy; Ian Teo | Zendy; Jaroslav Stark | Zendy; Nicola J. Rogers | Zendy; Thomas R. Rogers | Zendy; Elaine Bignell | Zendy; Ken Haynes | Zendy

Open Access

Impaired Interferon‐γ Responses, Increased Interleukin‐17 Expression, and a Tumor Necrosis Factor–α Transcriptional Program in Invasive Aspergillosis

Author(s) -

Darius ArmstrongJames,

Suzy A. Turnbull,

Ian Teo,

Jaroslav Stark,

Nicola J. Rogers,

Thomas R. Rogers,

Elaine Bignell,

Ken Haynes

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605931

Subject(s) - immunology , aspergillosis , neutropenia , calcineurin , immunity , tumor necrosis factor alpha , biology , interferon , interleukin , interferon gamma , cytokine , immune system , medicine , transplantation , chemotherapy , genetics

Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world. Historically, susceptibility to IA has been associated with prolonged neutropenia; however, IA has now become a major problem in patients on calcineurin inhibitors and allogenic hematopoietic stem cell transplant patients following engraftment. These observations suggest complex cellular mechanisms govern immunity to IA.

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