CXC Chemokine–Mediated Protection against Visceral Leishmaniasis: Involvement of the Proinflammatory Response | Zendy

Gaurav Gupta | Zendy; Surajit Bhattacharjee | Zendy; Sandip Bhattacharyya | Zendy; Parna Bhattacharya | Zendy; Anupam Adhikari | Zendy; Asok K. Mukherjee | Zendy; Suchandra Bhattacharyya Majumdar | Zendy; Subrata Majumdar | Zendy

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CXC Chemokine–Mediated Protection against Visceral Leishmaniasis: Involvement of the Proinflammatory Response

Author(s) -

Gaurav Gupta,

Surajit Bhattacharjee,

Sandip Bhattacharyya,

Parna Bhattacharya,

Anupam Adhikari,

Asok K. Mukherjee,

Suchandra Bhattacharyya Majumdar,

Subrata Majumdar

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605895

Subject(s) - proinflammatory cytokine , leishmania donovani , visceral leishmaniasis , chemokine , nitric oxide , immunology , mapk/erk pathway , nitric oxide synthase , biology , immune system , chemistry , kinase , leishmaniasis , inflammation , microbiology and biotechnology , endocrinology

Visceral leishmaniasis, caused by the protozoan parasite Leishmania donovani, is characterized by the loss of ability of the host to generate an effective immune response. In the present study, the comparative potential of CXC chemokines, interferon-gamma-inducible protein-10 (IP-10) and interleukin-8 (IL-8) in restricting Leishmania donovani infection via the release of nitric oxide and proinflammatory cytokines was studied in an in vitro model. Nitric oxide, a crucial mediator for IP-10-mediated leishmanicidal activity, was found to be dependent on inducible nitric oxide synthase 2 (iNOS2) expression and was linked to the mitogen-activated protein kinases (MAPK) signaling pathway. Further, IP-10 was also able to abrogate the survival of Leishmania in an in vivo model of visceral leishmaniasis by restoration of Th1 cytokines and nitric oxide. Thus, this study strongly demonstrates that IP-10, like CC chemokines, is involved in rendering a protective response in visceral leishmaniasis via up-regulation of proinflammatory mediators.

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