Recent Human Influenza A/H3N2 Virus Evolution Driven by Novel Selection Factors in Addition to Antigenic Drift | Zendy

Matthew J. Memoli | Zendy; Brett W. Jagger | Zendy; Vivien G. Dugan | Zendy; Li Qi | Zendy; Jadon P. Jackson | Zendy; Jeffery K. Taubenberger | Zendy

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Recent Human Influenza A/H3N2 Virus Evolution Driven by Novel Selection Factors in Addition to Antigenic Drift

Author(s) -

Matthew J. Memoli,

Brett W. Jagger,

Vivien G. Dugan,

Li Qi,

Jadon P. Jackson,

Jeffery K. Taubenberger

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605893

Subject(s) - biology , antigenic drift , hemagglutinin (influenza) , virology , virus , virulence , clade , influenza a virus , polymerase , viral evolution , genome , gene , antigenic variation , antigenic shift , influenza a virus subtype h5n1 , glycoprotein , h5n1 genetic structure , genetics , phylogenetics , disease , covid-19 , infectious disease (medical specialty) , medicine , pathology

Examination of the evolutionary dynamics of complete influenza viral genomes reveals that other processes, in conjunction with antigenic drift, play important roles in viral evolution and selection, but there is little biological evidence to support these genomic data. Previous work demonstrated that after the A/Fujian/411/2002-like H3N2 influenza A epidemic during 2003-2004, a preexisting nondominant Fujian-like viral clade gained a small number of changes in genes encoding the viral polymerase complex, along with several changes in the antigenic regions of hemagglutinin, and in a genome-wide selective sweep, it replaced other co-circulating H3N2 clades.

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