HIV‐1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV‐1 Infection | Zendy

Michael Santosuosso | Zendy; Elda Righi | Zendy; Victoria Lindstrom | Zendy; Pierre Leblanc | Zendy; Mark C. Poznansky | Zendy

Open Access

HIV‐1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV‐1 Infection

Author(s) -

Michael Santosuosso,

Elda Righi,

Victoria Lindstrom,

Pierre Leblanc,

Mark C. Poznansky

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605695

Subject(s) - immune system , lymphatic system , spleen , biology , immunology , lymph , virus , glycoprotein , in vitro , human immunodeficiency virus (hiv) , immunodeficiency , antibody , virology , medicine , pathology , microbiology and biotechnology , biochemistry

The envelope protein of human immunodeficiency virus type 1 (HIV-1)--glycoprotein 120 (gp120)--has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues and/or blood to elicit these effects. We found that gp120 was present in high concentrations (>300 pg/mL) in the spleen and lymph nodes of some of these individuals. In contrast, very low amounts of gp120 and p24 were detected in all serum samples tested. These findings underpin the clinical relevance of nonentry functions of gp120 and the chronic nature of human immunodeficiency virus (HIV)-induced immune dysregulation.

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