Open AccessProtection from Herpes Simplex Virus (HSV)–2 Infection with Replication‐Defective HSV‐2 or Glycoprotein D2 Vaccines in HSV‐1–Seropositive and HSV‐1–Seronegative Guinea Pigs
Author(s) -
Yo Hoshino,
Lesley Pesnicak,
Kennichi Dowdell,
Peter D. Burbelo,
David M. Knipe,
Stephen E. Straus,
Jeffrey I. Cohen
Publication year - 2009
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/605645
Subject(s) - virology , herpes simplex virus , viral shedding , neutralizing antibody , virus , immunology , biology , medicine , titer
A herpes simplex virus (HSV)-2 candidate vaccine consisting of glycoprotein D (gD2) in alum and monophosphoryl lipid A (MPL) reduced genital herpes disease in HSV-1-seronegative women but not in men or HSV-1-seropositive women.
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