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A herpes simplex virus (HSV)-2 candidate vaccine consisting of glycoprotein D (gD2) in alum and monophosphoryl lipid A (MPL) reduced genital herpes disease in HSV-1-seronegative women but not in men or HSV-1-seropositive women.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Protection from Herpes Simplex Virus (HSV)–2 Infection with Replication‐Defective HSV‐2 or Glycoprotein D2 Vaccines in HSV‐1–Seropositive and HSV‐1–Seronegative Guinea Pigs