Impact of Genetic Polymorphisms in Cytomegalovirus Glycoprotein B on Outcomes in Solid‐Organ Transplant Recipients with Cytomegalovirus Disease | Zendy

Oriol Manuel | Zendy; Anders Åsberg | Zendy; Xiaoli Pang | Zendy; Halvor Rollag | Zendy; Vincent C. Emery | Zendy; Jutta K. Preiksaitis | Zendy; Deepali Kumar | Zendy; Mark D. Pescovitz | Zendy; A Bignamini | Zendy; Anders Hartmann | Zendy; Alan G. Jardine | Zendy; Atul Humar | Zendy

Open Access

Impact of Genetic Polymorphisms in Cytomegalovirus Glycoprotein B on Outcomes in Solid‐Organ Transplant Recipients with Cytomegalovirus Disease

Author(s) -

Oriol Manuel,

Anders Åsberg,

Xiaoli Pang,

Halvor Rollag,

Vincent C. Emery,

Jutta K. Preiksaitis,

Deepali Kumar,

Mark D. Pescovitz,

A Bignamini,

Anders Hartmann,

Alan G. Jardine,

Atul Humar

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/605633

Subject(s) - genotype , serostatus , medicine , ganciclovir , viral load , cytomegalovirus , odds ratio , betaherpesvirinae , genotyping , immunology , human cytomegalovirus , virology , confidence interval , herpesviridae , viral disease , virus , biology , gene , biochemistry

It is unknown whether specific viral polymorphisms affect in vivo therapeutic response in patients with cytomegalovirus (CMV) disease. Polymorphisms in the CMV glycoprotein B (gB) gene allow discrimination of 4 distinct genotypes (gB1-gB4). We assessed the influence of gB genotypes on the clinical and virologic outcome of CMV disease.

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