Potential Antifungal Effects of Human Platelets against Zygomycetes In Vitro | Zendy

Susanne Perkhofer | Zendy; Barbara Kainzner | Zendy; Beate E. Kehrel | Zendy; Manfred P. Dierich | Zendy; Walter Nußbaumer | Zendy; Cornelia LassFlörl | Zendy

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Potential Antifungal Effects of Human Platelets against Zygomycetes In Vitro

Author(s) -

Susanne Perkhofer,

Barbara Kainzner,

Beate E. Kehrel,

Manfred P. Dierich,

Walter Nußbaumer,

Cornelia LassFlörl

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605607

Subject(s) - hypha , platelet , microbiology and biotechnology , conidium , biology , in vitro , antifungal , zygomycosis , immunology , botany , biochemistry , amphotericin b

Zygomycosis is increasingly recognized in immunocompromised hosts. We investigated whether platelets become activated after contact with Zygomycetes and adhere to conidial and hyphal structures using immunofluorescence. The platelets' influence on fungal viability was evaluated by assessing hyphal elongation and hyphal damage. Platelets became activated and strongly adhered to conidia and hyphae of Zygomycetes. Platelets induced time dependent damage to hyphae and significantly reduced (P<.05) hyphal elongation. We found that platelets possess antifungal capacities against Zygomycetes based on granule dependent mechanisms and significantly reduce fungal growth and spread, both of which are of major importance in evolving invasive disease.

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