Impact of Select Immunologic and Virologic Biomarkers on CD4 Cell Count Decrease in Patients with Chronic HIV‐1 Subtype C Infection: Results from Sinikithemba Cohort, Durban, South Africa | Zendy

Zabrina L. Brumme | Zendy; Bingxia Wang | Zendy; Kriebashne Nair | Zendy; Chanson J. Brumme | Zendy; Chantal de Pierres | Zendy; Shabashini Reddy | Zendy; Boris Jülg | Zendy; Eshia Moodley | Zendy; Christina Thobakgale | Zendy; Zhigang Lu | Zendy; Mary van der Stok | Zendy; Karen Bishop | Zendy; Zenele Mncube | Zendy; Fundisiwe Chonco | Zendy; Yuko Yuki | Zendy; Nicole Frahm | Zendy; Christian Brander | Zendy; Mary Carrington | Zendy; Kenneth A. Freedberg | Zendy; Photini Kiepiela | Zendy; Philip Goulder | Zendy; Bruce D. Walker | Zendy; Thumbi Ndung’u | Zendy; Elena Losina | Zendy

Open Access

Impact of Select Immunologic and Virologic Biomarkers on CD4 Cell Count Decrease in Patients with Chronic HIV‐1 Subtype C Infection: Results from Sinikithemba Cohort, Durban, South Africa

Author(s) -

Zabrina L. Brumme,

Bingxia Wang,

Kriebashne Nair,

Chanson J. Brumme,

Chantal de Pierres,

Shabashini Reddy,

Boris Jülg,

Eshia Moodley,

Christina Thobakgale,

Zhigang Lu,

Mary van der Stok,

Karen Bishop,

Zenele Mncube,

Fundisiwe Chonco,

Yuko Yuki,

Nicole Frahm,

Christian Brander,

Mary Carrington,

Kenneth A. Freedberg,

Photini Kiepiela,

Philip Goulder,

Bruce D. Walker,

Thumbi Ndung’u,

Elena Losina

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/605503

Subject(s) - immunology , viral load , cd8 , medicine , cohort , t cell , lentivirus , human leukocyte antigen , population , lymphocyte , immune system , virology , virus , antigen , viral disease , environmental health

The extent to which immunologic and clinical biomarkers influence human immunodeficiency virus type 1 (HIV-1) infection outcomes remains incompletely characterized, particularly for non-B subtypes. On the basis of data supporting in vitro HIV-1 protein-specific CD8 T lymphocyte responses as correlates of immune control in cross-sectional studies, we assessed the relationship of these responses, along with established HIV-1 biomarkers, with rates of CD4 cell count decrease in individuals infected with HIV-1 subtype C.

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