Cryptococcal Immune Reconstitution Inflammatory Syndrome after Antiretroviral Therapy in AIDS Patients with Cryptococcal Meningitis: A Prospective Multicenter Study | Zendy

Somnuek Sungkanuparph | Zendy; S. G. Filler | Zendy; Ploenchan Chetchotisakd | Zendy; Peter G. Pappas | Zendy; Tracy L. Nolen | Zendy; Weerawat Manosuthi | Zendy; Thanomsak Anekthana | Zendy; Michele I. Morris | Zendy; Khuanchai Supparatpinyo | Zendy; Heather Kopetskie | Zendy; Amy Kendrick | Zendy; Philip C. Johnson | Zendy; Jack D. Sobel | Zendy; Robert A. Larsen | Zendy

Open Access

Cryptococcal Immune Reconstitution Inflammatory Syndrome after Antiretroviral Therapy in AIDS Patients with Cryptococcal Meningitis: A Prospective Multicenter Study

Author(s) -

Somnuek Sungkanuparph,

S. G. Filler,

Ploenchan Chetchotisakd,

Peter G. Pappas,

Tracy L. Nolen,

Weerawat Manosuthi,

Thanomsak Anekthana,

Michele I. Morris,

Khuanchai Supparatpinyo,

Heather Kopetskie,

Amy Kendrick,

Philip C. Johnson,

Jack D. Sobel,

Robert A. Larsen

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/605497

Subject(s) - immune reconstitution inflammatory syndrome , medicine , cryptococcal meningitis , cryptococcosis , prospective cohort study , immunology , meningitis , antiretroviral therapy , human immunodeficiency virus (hiv) , viral disease , viral load , surgery

A prospective multicenter study of cryptococcal immune reconstitution inflammatory syndrome (IRIS) was conducted as a substudy of the Bacteriology and Mycology Study Group 3-01. Of 101 AIDS patients with cryptococcal meningitis who received highly active antiretroviral therapy (HAART), 13 experienced cryptococcal IRIS. No association between the timing of HAART initiation and the diagnosis of IRIS was identified. Increased baseline serum cryptococcal antigen (CrAg) titer was a risk factor for cryptococcal IRIS.

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