Phosphoantigen‐Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte‐Derived Macrophages Infected with Human and Avian Influenza Viruses | Zendy

Gang Qin | Zendy; Huawei Mao | Zendy; Jian Zheng | Zendy; Sin Fun Sia | Zendy; Yinping Liu | Zendy; PingLung Chan | Zendy; K. H. Lam | Zendy; Malik Peiris | Zendy; YL Lau | Zendy; Wenwei Tu | Zendy

Open Access

Phosphoantigen‐Expanded Human γδ T Cells Display Potent Cytotoxicity against Monocyte‐Derived Macrophages Infected with Human and Avian Influenza Viruses

Author(s) -

Gang Qin,

Huawei Mao,

Jian Zheng,

Sin Fun Sia,

Yinping Liu,

PingLung Chan,

K. H. Lam,

Malik Peiris,

YL Lau,

Wenwei Tu

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605413

Subject(s) - virology , virus , influenza a virus subtype h5n1 , pandemic , biology , influenza a virus , human influenza , monocyte , cytotoxicity , orthomyxoviridae , immunology , microbiology and biotechnology , medicine , in vitro , covid-19 , disease , infectious disease (medical specialty) , biochemistry , pathology

Influenza virus is a cause of substantial annual morbidity and mortality worldwide. The potential emergence of a new pandemic strain (eg, avian influenza virus) is a major concern. Currently available vaccines and anti-influenza drugs have limited effectiveness for influenza virus infections, especially for new pandemic strains. Therefore, there is an acute need to develop alternative strategies for influenza therapy. gammadelta T cells have potent antiviral activities against different viruses, but no data are available concerning their antiviral activity against influenza viruses.

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