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Because a previous rotavirus vaccine was associated with intussusception, new rotavirus vaccines are monitored postlicensure for any such association. Accurate background intussusception rates are needed to determine whether the number of cases observed after vaccination exceeds that expected by chance. Previously, intussusception rates were obtained from inpatient discharge databases. We sought to determine the rate of intussusception among infants managed only with short-stay or emergency department care.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Underestimates of Intussusception Rates among US Infants Based on Inpatient Discharge Data: Implications for Monitoring the Safety of Rotavirus Vaccines