Underestimates of Intussusception Rates among US Infants Based on Inpatient Discharge Data: Implications for Monitoring the Safety of Rotavirus Vaccines | Zendy

Margaret M. Cortese | Zendy; Mary Allen Staat | Zendy; Geoffrey A. Weinberg | Zendy; Kathryn M. Edwards | Zendy; Marilyn A. Rice | Zendy; Peter G. Szilagyi | Zendy; Caroline Breese Hall | Zendy; Daniel C. Payne | Zendy; Umesh D. Parashar | Zendy

Open Access

Underestimates of Intussusception Rates among US Infants Based on Inpatient Discharge Data: Implications for Monitoring the Safety of Rotavirus Vaccines

Author(s) -

Margaret M. Cortese,

Mary Allen Staat,

Geoffrey A. Weinberg,

Kathryn M. Edwards,

Marilyn A. Rice,

Peter G. Szilagyi,

Caroline Breese Hall,

Daniel C. Payne,

Umesh D. Parashar

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/605055

Subject(s) - medicine , intussusception (medical disorder) , rotavirus vaccine , diagnosis code , emergency department , vaccination , incidence (geometry) , pediatrics , rotavirus , medical record , emergency medicine , hospital discharge , surgery , general surgery , population , diarrhea , environmental health , virology , physics , psychiatry , optics

Because a previous rotavirus vaccine was associated with intussusception, new rotavirus vaccines are monitored postlicensure for any such association. Accurate background intussusception rates are needed to determine whether the number of cases observed after vaccination exceeds that expected by chance. Previously, intussusception rates were obtained from inpatient discharge databases. We sought to determine the rate of intussusception among infants managed only with short-stay or emergency department care.

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