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A rotavirus vaccine previously licensed in the United States was withdrawn because it caused intussusception. Data on background intussusception rates in developing countries are required to plan pre- and postlicensure safety studies for new rotavirus vaccines. Also, it is unclear whether natural rotavirus infection is associated with intussusception.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Population‐Based Incidence of Intussusception and a Case‐Control Study to Examine the Association of Intussusception with Natural Rotavirus Infection among Indian Children