Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV‐Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients | Zendy

Tihana Bicanic | Zendy; Conrad Muzoora | Zendy; Annemarie E. Brouwer | Zendy; Graeme Meintjes | Zendy; Nicky Longley | Zendy; Kabanda Taseera | Zendy; Kevin Rebe | Zendy; Angela Loyse | Zendy; Joseph N Jarvis | Zendy; LindaGail Bekker | Zendy; Robin Wood | Zendy; Direk Limmathurotsakul | Zendy; Wirongrong Chierakul | Zendy; Kasia Stepniewska | Zendy; Nicholas J. White | Zendy; Shabbar Jaffar | Zendy; Thomas S. Harrison | Zendy

Open Access

Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV‐Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients

Author(s) -

Tihana Bicanic,

Conrad Muzoora,

Annemarie E. Brouwer,

Graeme Meintjes,

Nicky Longley,

Kabanda Taseera,

Kevin Rebe,

Angela Loyse,

Joseph N Jarvis,

LindaGail Bekker,

Robin Wood,

Direk Limmathurotsakul,

Wirongrong Chierakul,

Kasia Stepniewska,

Nicholas J. White,

Shabbar Jaffar,

Thomas S. Harrison

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/604716

Subject(s) - cryptococcal meningitis , medicine , clinical endpoint , fluconazole , cohort , antifungal , surrogate endpoint , human immunodeficiency virus (hiv) , meningitis , cohort study , immunology , clinical trial , surgery , viral disease , dermatology

Progress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of clearance of infection, based on serial quantitative cultures of cerebrospinal fluid, to differentiate the fungicidal activity of alternative antifungal drug regimens. We hypothesized that the rate of clearance of infection should also be a clinically meaningful endpoint.

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