Dexamethasone inCryptococcus gattiiCentral Nervous System Infection | Zendy

Peter Phillips | Zendy; Kristine Chapman | Zendy; Madeleine Sharp | Zendy; Phil Harrison | Zendy; J Vortel | Zendy; Theodore S. Steiner | Zendy; William Bowie | Zendy

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Dexamethasone inCryptococcus gattiiCentral Nervous System Infection

Author(s) -

Peter Phillips,

Kristine Chapman,

Madeleine Sharp,

Phil Harrison,

J Vortel,

Theodore S. Steiner,

William Bowie

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/603554

Subject(s) - dexamethasone , medicine , cryptococcosis , cryptococcus gattii , central nervous system , cerebrospinal fluid , cryptococcus neoformans , meningitis , cryptococcus , intracranial pressure , immunology , surgery , microbiology and biotechnology , biology

Clinical outcomes were reviewed for 4 patients with Cryptococcus gattii central nervous system infection who received dexamethasone for the treatment of persisting mental status abnormalities and focal lesions on brain scan despite culture-negative cerebrospinal fluid and the management of intracranial pressure. Favorable clinical responses were observed in 3 patients. Although corticosteroids are not recommended for the treatment of cryptococcal meningitis, these observations suggest that dexamethasone should be further evaluated in this subset of patients.

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