MIF(Macrophage Migration Inhibitory Factor) Promoter Polymorphisms and Susceptibility to Severe Malarial Anemia
Author(s) -
Gordon A. Awandare,
Jeremy Martinson,
Tom Were,
Collins Ouma,
Gregory C. Davenport,
John Michael Ong’echa,
Wenkui Wang,
Lin Leng,
Robert E. Ferrell,
Richard Bucala,
Douglas J. Perkins
Publication year - 2009
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/600894
Subject(s) - macrophage migration inhibitory factor , haplotype , immunology , sma* , biology , pathogenesis , malaria , plasmodium falciparum , allele , genetics , gene , cytokine , mathematics , combinatorics
Severe malarial anemia (SMA) resulting from Plasmodium falciparum infection is one of the leading causes of childhood mortality in sub-Saharan Africa. The innate immune mediator macrophage migration inhibitory factor (MIF) plays a critical role in the pathogenesis of SMA.
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