Relationship between Initial Vancomycin Concentration‐Time Profile and Nephrotoxicity among Hospitalized Patients | Zendy

Thomas P. Lodise | Zendy; Nimish Patel | Zendy; Ben M. Lomaestro | Zendy; Keith A. Rodvold | Zendy; George L. Drusano | Zendy

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Relationship between Initial Vancomycin Concentration‐Time Profile and Nephrotoxicity among Hospitalized Patients

Author(s) -

Thomas P. Lodise,

Nimish Patel,

Ben M. Lomaestro,

Keith A. Rodvold,

George L. Drusano

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/600884

Subject(s) - vancomycin , medicine , nephrotoxicity , creatinine , trough level , trough concentration , area under the curve , antibiotics , surgery , gastroenterology , pharmacokinetics , urology , toxicity , staphylococcus aureus , transplantation , tacrolimus , biology , bacteria , microbiology and biotechnology , genetics

Data suggest that higher doses of vancomycin can increase the risk of nephrotoxicity. No study has been undertaken to determine the pharmacodynamic index (ie, the area under the curve [AUC] or the trough value) that best describes the relationship between vancomycin exposure and onset of nephrotoxicity.

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