Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia | Zendy

Ernesto Hinojosa | Zendy; Angela R. Boyd | Zendy; Carlos J. Orihuela | Zendy

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Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

Author(s) -

Ernesto Hinojosa,

Angela R. Boyd,

Carlos J. Orihuela

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/600870

Subject(s) - inflammation , proinflammatory cytokine , immunology , tumor necrosis factor alpha , streptococcus pneumoniae , cytokine , platelet activating factor receptor , receptor , pneumonia , toll like receptor , medicine , biology , microbiology and biotechnology , immune system , innate immune system , antagonist , antibiotics

Aging is associated with increased inflammation and risk of community-acquired pneumonia. Streptococcus pneumoniae co-opts the nuclear factor kappa B (NFkB)-regulated proteins polymeric immunoglobulin receptor (pIgR) and platelet-activating factor receptor (PAFr) to attach and invade cells. We sought to determine whether aging and chronic inflammation were associated with increased pIgR and PAFr levels in the lungs and increased susceptibility to S. pneumoniae infection.

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