Rotavirus and the Indigenous Children of the Australian Outback: Monovalent Vaccine Effective in a High‐Burden Setting | Zendy

Tom Snelling | Zendy; Rosalie Schultz | Zendy; Julie Graham | Zendy; Robert Roseby | Zendy; Graeme Barnes | Zendy; Ross Andrews | Zendy; Jonathan R. Carapetis | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Rotavirus and the Indigenous Children of the Australian Outback: Monovalent Vaccine Effective in a High‐Burden Setting

Author(s) -

Tom Snelling,

Rosalie Schultz,

Julie Graham,

Robert Roseby,

Graeme Barnes,

Ross Andrews,

Jonathan R. Carapetis

Publication year - 2009

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/600395

Subject(s) - medicine , rotavirus vaccine , rotavirus , outbreak , rotavirus gastroenteritis , confidence interval , vaccination , pediatrics , indigenous , virology , vaccine efficacy , reoviridae , environmental health , virus , ecology , biology

Indigenous children living in arid Central Australia experience frequent outbreaks of rotavirus gastroenteritis. A widespread outbreak of G9 rotavirus infection occurred several months after introduction of the RIX4414 rotavirus vaccine. We performed a retrospective case-control study to determine vaccine efficacy during the outbreak. Two doses provided an estimated vaccine efficacy of 77.7% (95% confidence interval, 40.2%-91.7%) against hospitalization for gastroenteritis. Vaccine efficacy was 84.5% (95% confidence interval, 23.4%-96.9%) against confirmed cases of rotavirus infection. Vaccination was effective in this high-burden setting.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research