Analysis ofPlasmodium falciparum varGenes Expressed in Children from Papua New Guinea | Zendy

Nicole Falk | Zendy; Mirjam Kaestli | Zendy; Weihong Qi | Zendy; Michael Ott | Zendy; Kay Baea | Zendy; Alfred Cortés | Zendy; HansPeter Beck | Zendy

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Analysis ofPlasmodium falciparum varGenes Expressed in Children from Papua New Guinea

Author(s) -

Nicole Falk,

Mirjam Kaestli,

Weihong Qi,

Michael Ott,

Kay Baea,

Alfred Cortés,

HansPeter Beck

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/600071

Subject(s) - biology , parasitemia , gene , subtelomere , malaria , genetics , plasmodium falciparum , antigenic variation , genome , immunology

The variable antigen P. falciparum erythrocyte membrane protein-1 (PfEMP1) is a major virulence factor in malaria. A large number of var genes encode PfEMP1, and we hypothesized that a restricted PfEMP1 repertoire determines clinical disease presentation. We conducted a case-control study in Papua New Guinea and analyzed transcribed var genes in naturally infected children.

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