Antibodies to Variant Surface Antigens ofPlasmodium falciparum–Infected Erythrocytes Are Associated with Protection from Treatment Failure and the Development of Anemia in Pregnancy | Zendy

Gaoqian Feng | Zendy; Elizabeth H. Aitken | Zendy; Francisca Yosaatmadja | Zendy; Linda Kalilani | Zendy; Steven R. Meshnick | Zendy; Anthony Jaworowski | Zendy; J. A. Simpson | Zendy; Stephen J. Rogerson | Zendy

Open Access

Antibodies to Variant Surface Antigens ofPlasmodium falciparum–Infected Erythrocytes Are Associated with Protection from Treatment Failure and the Development of Anemia in Pregnancy

Author(s) -

Gaoqian Feng,

Elizabeth H. Aitken,

Francisca Yosaatmadja,

Linda Kalilani,

Steven R. Meshnick,

Anthony Jaworowski,

J. A. Simpson,

Stephen J. Rogerson

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/599841

Subject(s) - antibody , parasitemia , anemia , immunology , malaria , antigen , pregnancy , plasmodium falciparum , immunity , medicine , immunoglobulin g , biology , immune system , genetics

In pregnancy-associated malaria (PAM), Plasmodium falciparum-infected erythrocytes (IEs) express variant surface antigens (VSA-PAM) that evade existing immunity and mediate placental sequestration. Antibodies to VSA-PAM develop with gravidity and block placental adhesion or opsonize IEs for phagocytic clearance, helping to prevent maternal anemia and low birth weight in infants.

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