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In pregnancy-associated malaria (PAM), Plasmodium falciparum-infected erythrocytes (IEs) express variant surface antigens (VSA-PAM) that evade existing immunity and mediate placental sequestration. Antibodies to VSA-PAM develop with gravidity and block placental adhesion or opsonize IEs for phagocytic clearance, helping to prevent maternal anemia and low birth weight in infants.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Antibodies to Variant Surface Antigens of<i>Plasmodium falciparum</i>–Infected Erythrocytes Are Associated with Protection from Treatment Failure and the Development of Anemia in Pregnancy

Antibodies to Variant Surface Antigens ofPlasmodium falciparum–Infected Erythrocytes Are Associated with Protection from Treatment Failure and the Development of Anemia in Pregnancy