Open AccessInterleukin 17 Production among Patients with American Cutaneous Leishmaniasis
Author(s) -
Olı́via Bacellar,
Daniela Faria,
Márcia Nascimento,
Thiago M. Cardoso,
Kenneth J. Gollob,
Walderez O. Dutra,
Phillip Scott,
Edgar M. Carvalho
Publication year - 2009
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1086/599380
Subject(s) - cutaneous leishmaniasis , leishmaniasis , immunology , inflammation , interleukin 17 , pathogenesis , interleukin , autoimmunity , interleukin 10 , medicine , leishmania , leishmania major , cytokine , biology , immune system , parasite hosting , world wide web , computer science
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r2 = 0.86; P<.001) These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.
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