Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence | Zendy

Odile B. Harrison | Zendy; Nicholas J. Evans | Zendy; Jessica M. A. Blair | Zendy; Holly S. Grimes | Zendy; Colin R. Tinsley | Zendy; Xavier Nassif | Zendy; Paula Kriz | Zendy; Roisin Ure | Zendy; Steve Gray | Zendy; Jeremy P. Derrick | Zendy; Martin Maiden | Zendy; Ian M. Feavers | Zendy

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Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence

Author(s) -

Odile B. Harrison,

Nicholas J. Evans,

Jessica M. A. Blair,

Holly S. Grimes,

Colin R. Tinsley,

Xavier Nassif,

Paula Kriz,

Roisin Ure,

Steve Gray,

Jeremy P. Derrick,

Martin Maiden,

Ian M. Feavers

Publication year - 2009

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1086/599377

Subject(s) - neisseria meningitidis , meningococcal disease , neisseria , neisseriaceae , locus (genetics) , microbiology and biotechnology , biology , virulence , carriage , neisseria gonorrhoeae , molecular epidemiology , gene , multilocus sequence typing , virology , genetics , bacteria , genotype , medicine , antibiotics , pathology

The distribution of the hemoglobin receptor gene (hmbR) was investigated among disease and carriage Neisseria meningitidis isolates, revealing that the gene was detected at a significantly higher frequency among disease isolates than among carriage isolates. In isolates without hmbR, the locus was occupied by the cassettes exl2 or exl3 or by a "pseudo hmbR" gene, designated exl4. The hmbR locus exhibited characteristics of a pathogenicity island in published genomes of N. meningitidis, Neisseria gonorrhoeae, and Neisseria lactamica sequence type-640. These data are consistent with a role for the hmbR gene in meningococcal disease.

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